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425642-32-6

425642-32-6 structure
425642-32-6 structure
  • Name: GLYCEROPHOSPHOINOSITOL CHOLINE
  • Chemical Name: GLYCEROPHOSPHOINOSITOL CHOLINE
  • CAS Number: 425642-32-6
  • Molecular Formula: C14H32NO12P
  • Molecular Weight: 437.377
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
  • Create Date: 2021-09-12 20:17:43
  • Modify Date: 2025-08-20 15:50:04
  • Glycerophosphoinositol choline is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders[1][2].
Name GLYCEROPHOSPHOINOSITOL CHOLINE
Synonyms GLYCEROPHOSPHOINOSITOL CHOLINE
2-Hydroxy-N,N,N-trimethylethanaminium (2R)-2,3-dihydroxypropyl (1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl phosphate
Description Glycerophosphoinositol choline is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders[1][2].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Glycerophosphoinositol choline (0 or 70 μM, 4 days) can effectively mitigate apoptosis and maintain cell viability[1]. Cell Viability Assay[1] Cell Line: Rat pheochromocytoma cells PC12 Concentration: 0 or 70 μM Incubation Time: 4 days Result: Showed the cell viability of 94% at 70 μM while cell viability of 83% at 0 μM. Reduced the number of cells with DNA breaks (characteristic of apoptosis) by 8.5% at 70 μM compared to the no treatment group.
In Vivo Glycerophosphoinositol choline (s.c., 0.2 and 100 mg/kg/h, 24 or 48 hours) can reduce postoperative injurious reflexes and effectively decreases tumor necrosis factor (TNF) release from macrophages in female C57/Bl6 mice[2]. Animal Model: Postoperative pain model of female C57/Bl6 mice[2] Dosage: 0.2 and 100 mg/kg/h Administration: Subcutaneous injection, 24 or 48 hours Result: Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED50 value of choline dose was 1.7 mg/kg/h. Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED50 value of 4.7 mg/kg/h but not 24 hours.
References

[1]. M Q Holmes-McNary, et al. Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Brain Res Dev Brain Res. 1997 Jul 18;101(1-2):9-16.

[2]. T J Rowley, et al. Antinociceptive and anti-inflammatory effects of choline in a mouse model of postoperative pain. Br J Anaesth. 2010 Aug;105(2):201-7.
Molecular Formula C14H32NO12P
Molecular Weight 437.377
Exact Mass 437.166199
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