324029-01-8

324029-01-8 structure

Name: AKTide-2T TFA
Chemical Name: AKTide-2T
CAS Number: 324029-01-8
Molecular Formula: C₇₄H₁₁₄N₂₈O₂₀
Molecular Weight: 1715.87000
Catalog: Signaling Pathways PI3K/Akt/mTOR Akt
Create Date: 2018-12-26 18:58:25
Modify Date: 2024-01-13 21:56:49
AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position[1].

Name	AKTide-2T
Synonyms	ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA ARKRERTYSFGHHA H-ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA-OH AKT/PKB/Rac-Protein Kinase Substrate Substrate for AKT/PKB/Rac-protein Kinase

Description	AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	Akt
In Vitro	AKTide-2T mimics the optimal phosphorylation sequence of Akt, and inhibits Akt phosphorylated Hsp27 by addition of 20 μM Akt inhibitory peptide[1].
References	[1]. T Obata,et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem. 2000 Nov 17;275(46):36108-15. [2]. Madhavi J Rane, et al. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem. 2003 Jul 25;278(30):27828-35.