AKTide-2T TFA

Modify Date: 2024-01-13 21:56:49

AKTide-2T TFA Structure
AKTide-2T TFA structure
Common Name AKTide-2T TFA
CAS Number 324029-01-8 Molecular Weight 1715.87000
Density N/A Boiling Point N/A
Molecular Formula C74H114N28O20 Melting Point 153-156ºC
MSDS N/A Flash Point N/A

 Use of AKTide-2T TFA


AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position[1].

 Names

Name AKTide-2T
Synonym More Synonyms

 AKTide-2T TFA Biological Activity

Description AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position[1].
Related Catalog
Target

Akt

In Vitro AKTide-2T mimics the optimal phosphorylation sequence of Akt, and inhibits Akt phosphorylated Hsp27 by addition of 20 μM Akt inhibitory peptide[1].
References

[1]. T Obata,et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem. 2000 Nov 17;275(46):36108-15.

[2]. Madhavi J Rane, et al. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem. 2003 Jul 25;278(30):27828-35.

 Chemical & Physical Properties

Melting Point 153-156ºC
Molecular Formula C74H114N28O20
Molecular Weight 1715.87000
Exact Mass 1714.88000
PSA 808.69000
LogP 0.70630
Storage condition -20°C

 Synonyms

ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA
ARKRERTYSFGHHA
H-ALA-ARG-LYS-ARG-GLU-ARG-THR-TYR-SER-PHE-GLY-HIS-HIS-ALA-OH
AKT/PKB/Rac-Protein Kinase Substrate
Substrate for AKT/PKB/Rac-protein Kinase