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Product Name: (R,S)-N-ACETYL-3,4-DIMETHOXYPHENYLALANINE
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138199-51-6

138199-51-6 structure

Name: (RS)-(Tetrazol-5-yl)glycine
Chemical Name: 2-amino-2-(2H-tetrazol-5-yl)acetic acid
CAS Number: 138199-51-6
Molecular Formula: C₃H₅N₅O₂
Molecular Weight: 143.10400
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-12-20 20:33:27
Modify Date: 2024-01-11 22:55:58
(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist[1]. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively[2]. (RS)-(Tetrazol-5-yl)glycine induces seizure responses and Fos in mice[3].

Name	2-amino-2-(2H-tetrazol-5-yl)acetic acid
Synonyms	Mepyramine maleate Tetrazol-5-yl-gly Tetrazolylglycine Tet-glycine 5-Tetrazolyl-glycine

Description	(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist[1]. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively[2]. (RS)-(Tetrazol-5-yl)glycine induces seizure responses and Fos in mice[3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	EC50: 99 nM (GluN1/GluN2D) and 1.7 μM (GluN1/GluN2A)[1]
In Vitro	(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a agonist of N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor. (RS)-(Tetrazol-5-yl)glycine displaces NMDA receptor binding to rat brain membranes as measured using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands[1]. (RS)-(Tetrazol-5-yl)glycine does not appreciably inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM)[1].
In Vivo	(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine; 1.25, 1.5 mg/kg; IP) induces seizure responses and Fos in the NR1+/+ and NR1-/- mice[3]. (RS)-(Tetrazol-5-yl)glycine is a highly potent convulsant when given to neonatal rats (ED50=0.071 mg/kg; i.p.) [1]. Animal Model: C57BL/6 mice[3] Dosage: 1.25, 1.5 mg/kg Administration: IP Result: Induced seizure responses and Fos.
References	[1]. Schoepp DD, et al. D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. Eur J Pharmacol. 1991 Oct 15;203(2):237-43. [2]. Vance KM, et al. Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nat Commun. 2011;2:294. [3]. Duncan GE, et al. Seizure responses and induction of Fos by the NMDA agonist (tetrazol-5-yl)glycine in a geneticmodel of NMDA receptor hypofunction. Brain Res. 2008 Jul 24;1221:41-8.

Density	1.804 g/cm3
Boiling Point	447.1ºC at 760 mmHg
Molecular Formula	C₃H₅N₅O₂
Molecular Weight	143.10400
Flash Point	224.2ºC
Exact Mass	143.04400
PSA	117.78000
Vapour Pressure	8.91E-09mmHg at 25°C
Index of Refraction	1.669

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