4674-50-4

4674-50-4 structure

Name: Nootkatone
Chemical Name: (+)-Nootkatone
CAS Number: 4674-50-4
Molecular Formula: C₁₅H₂₂O
Molecular Weight: 218.335
Catalog: Flavors and spices Synthetic spice Ketone fragrance Decenone
Create Date: 2018-09-05 23:01:02
Modify Date: 2024-01-02 22:30:18
Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2].

Name	(+)-Nootkatone
Synonyms	(4R,4aS,6R)-6-Isopropenyl-4,4a-dimethyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone 2(3H)-Naphthalenone, 4,4a,5,6,7,8-hexahydro-4,4a-dimethyl-6-(1-methylethenyl)-, (4R,4aS,6R)- EINECS 225-124-4 MFCD00036591 4βh,5α-eremophila-1(10),11-dien-2-one Nootkatone Nootkatone, (+)-

Description	Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Nootkatone (10 mg/kg) group shows good performance in behavior experiments including Y-maze test and Morris water maze test. The results of histopathological examination and immunohistochemical analysis showed that LPS induced degeneration of neurons and activation of microglia particularly in hippocampus and Nootkatone (10 mg/kg) reversed these changes. Enzyme linked immunosorbent assay and western blot analysis also demonstrated that the model group had increased expression of IL-1β, IL-6, TNF-α, NLRP3 and NF-κB p65, especially in hippocampus relative to sham-operated group, and Nootkatone (10 mg/kg) decreased the high expression of these inflammatory cytokines[1].
References	[1]. Wang Y, et al. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. Int Immunopharmacol. 2018 Sep;62:77-85. [2]. Wang Y, et al. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. Int Immunopharmacol. 2018 Sep;62:77-85.

Density	1.0±0.1 g/cm3
Boiling Point	318.6±42.0 °C at 760 mmHg
Melting Point	35-39ºC
Molecular Formula	C₁₅H₂₂O
Molecular Weight	218.335
Flash Point	142.1±18.7 °C
Exact Mass	218.167068
PSA	17.07000
LogP	3.84
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.503
Storage condition	2-8°C
Stability	Stable. Incompatible with strong oxidizing agents.
Water Solubility	Slightly soluble in ethanol and chloroform. Partly soluble in water.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317
Precautionary Statements	P280
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2