Nootkatone
Modify Date: 2024-01-02 22:30:18
Nootkatone structure
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Common Name | Nootkatone | ||
|---|---|---|---|---|
| CAS Number | 4674-50-4 | Molecular Weight | 218.335 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 318.6±42.0 °C at 760 mmHg | |
| Molecular Formula | C15H22O | Melting Point | 35-39ºC | |
| MSDS | Chinese USA | Flash Point | 142.1±18.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of NootkatoneNootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2]. |
| Name | (+)-Nootkatone |
|---|---|
| Synonym | More Synonyms |
| Description | Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects[1]. Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease[2]. |
|---|---|
| Related Catalog | |
| In Vivo | Nootkatone (10 mg/kg) group shows good performance in behavior experiments including Y-maze test and Morris water maze test. The results of histopathological examination and immunohistochemical analysis showed that LPS induced degeneration of neurons and activation of microglia particularly in hippocampus and Nootkatone (10 mg/kg) reversed these changes. Enzyme linked immunosorbent assay and western blot analysis also demonstrated that the model group had increased expression of IL-1β, IL-6, TNF-α, NLRP3 and NF-κB p65, especially in hippocampus relative to sham-operated group, and Nootkatone (10 mg/kg) decreased the high expression of these inflammatory cytokines[1]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 318.6±42.0 °C at 760 mmHg |
| Melting Point | 35-39ºC |
| Molecular Formula | C15H22O |
| Molecular Weight | 218.335 |
| Flash Point | 142.1±18.7 °C |
| Exact Mass | 218.167068 |
| PSA | 17.07000 |
| LogP | 3.84 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.503 |
| Storage condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Water Solubility | Slightly soluble in ethanol and chloroform. Partly soluble in water. |
| Precursor 10 | |
|---|---|
| DownStream 1 | |
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| (4R,4aS,6R)-6-Isopropenyl-4,4a-dimethyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone |
| 2(3H)-Naphthalenone, 4,4a,5,6,7,8-hexahydro-4,4a-dimethyl-6-(1-methylethenyl)-, (4R,4aS,6R)- |
| EINECS 225-124-4 |
| MFCD00036591 |
| 4βh,5α-eremophila-1(10),11-dien-2-one |
| Nootkatone |
| Nootkatone, (+)- |
- BioBioPha
- China
- Product Name: Nootkatone
- Price: ￥Inquiry/50mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Nootkatone
- Price: ￥198.0/20mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
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Price: ￥858/250mg
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