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371924-24-2

371924-24-2 structure
371924-24-2 structure
  • Name: MCU-i4
  • Chemical Name: MCU-i4
  • CAS Number: 371924-24-2
  • Molecular Formula: C23H27N3O2
  • Molecular Weight: 377.48
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2021-09-12 18:14:45
  • Modify Date: 2025-08-25 19:28:48
  • MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2].

Name MCU-i4
Synonyms MFCD02730422
Description MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2].
Related Catalog
In Vitro MCU-i4 modulates mitochondrial Ca2+ uptake to 1 min of incubation, i.e., exerting a negative modulation, indicating that the primary effect of these compounds is a sudden and direct modulation of MCU complex activity[1]. MCU-i4 exerted a negative effect on Δψ. MCU-i4 has no effect on cell viability[1]. Cell Differentiation Assay[1] Cell Line: Growing medium of 90% confluent C2C12 myoblasts. Concentration: 10 μM. Incubation Time: 24 h. Result: Decreased myotube width.
References

[1]. Giulia Di Marco, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6.

[2]. Alessandro Rimessi, et al. Update on Calcium Signaling in Cystic Fibrosis Lung Disease. Front Pharmacol. 2021 Mar 11;12:581645.

Molecular Formula C23H27N3O2
Molecular Weight 377.48
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