2415263-07-7

2415263-07-7 structure

Name: Thalidomide-O-amido-C8-NH2 hydrochloride
Chemical Name: Thalidomide-O-amido-C8-NH2 hydrochloride
CAS Number: 2415263-07-7
Molecular Formula: C₂₃H₃₁ClN₄O₆
Molecular Weight: 494.97
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2021-09-17 13:19:50
Modify Date: 2024-01-16 20:23:21
Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

Name	Thalidomide-O-amido-C8-NH2 hydrochloride

Description	Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	Thalidomide-O-amido-C8-NH2 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is bound lo at least one targeting ligand. Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein (s)[1].
References	[1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.

Molecular Formula	C₂₃H₃₁ClN₄O₆
Molecular Weight	494.97

Hazard Codes	Xi