435327-40-5

435327-40-5 structure

Name: Avasopasem manganese
Chemical Name: Avasopasem manganese
CAS Number: 435327-40-5
Molecular Formula: C₂₁H₃₁Cl₂MnN₅
Molecular Weight: 479.35
Catalog: Research Areas Cancer
Create Date: 2021-09-10 11:58:55
Modify Date: 2024-01-07 06:30:38
Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O2*- to hydrogen peroxide (H2O2), arresting the initiation of this cascade. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer[1].

Name	Avasopasem manganese

Description	Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O2*- to hydrogen peroxide (H2O2), arresting the initiation of this cascade. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vivo	Avasopasem manganese is an agent intended to interrupt severe oral mucositis pathogenesis, to reduce the duration, incidence, and severity of radiation-induced oral mucositis[1].
References	[1]. Anderson CM, et al. Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer [published correction appears in J Clin Oncol. 2020 Jan 20;38(3):288]. J Clin Oncol. 2019;37(34):3256-3265.

Molecular Formula	C₂₁H₃₁Cl₂MnN₅
Molecular Weight	479.35