1391385-57-1
1391385-57-1 structure
- Name: CaV1.3 antagonist-1
- Chemical Name: CaV1.3 antagonist-1
- CAS Number: 1391385-57-1
- Molecular Formula: C17H19ClN2O3
- Molecular Weight: 334.80
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
- Create Date: 2021-09-13 13:29:04
- Modify Date: 2024-01-09 08:15:35
-
CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research[1].
| Name | CaV1.3 antagonist-1 |
|---|
| Description | CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research[1]. |
|---|---|
| Related Catalog | |
| Target |
CaV1.3:1.7 μM (IC50) |
| In Vitro | CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for CaV1.3 and CaV1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay[1]. |
| References |
| Molecular Formula | C17H19ClN2O3 |
|---|---|
| Molecular Weight | 334.80 |