1391385-57-1

1391385-57-1 structure

Name: CaV1.3 antagonist-1
Chemical Name: CaV1.3 antagonist-1
CAS Number: 1391385-57-1
Molecular Formula: C₁₇H₁₉ClN₂O₃
Molecular Weight: 334.80
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2021-09-13 13:29:04
Modify Date: 2024-01-09 08:15:35
CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research[1].

Name	CaV1.3 antagonist-1

Description	CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease
Target	CaV1.3:1.7 μM (IC50)
In Vitro	CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for CaV1.3 and CaV1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay[1].
References	[1]. Soosung Kang, et al. CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease. Nat Commun. 2012;3:1146.

Molecular Formula	C₁₇H₁₉ClN₂O₃
Molecular Weight	334.80