CaV1.3 antagonist-1
Modify Date: 2024-01-09 08:15:35
CaV1.3 antagonist-1 structure
|
Common Name | CaV1.3 antagonist-1 | ||
|---|---|---|---|---|
| CAS Number | 1391385-57-1 | Molecular Weight | 334.80 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H19ClN2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CaV1.3 antagonist-1CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research[1]. |
| Name | CaV1.3 antagonist-1 |
|---|
| Description | CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research[1]. |
|---|---|
| Related Catalog | |
| Target |
CaV1.3:1.7 μM (IC50) |
| In Vitro | CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for CaV1.3 and CaV1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay[1]. |
| References |
| Molecular Formula | C17H19ClN2O3 |
|---|---|
| Molecular Weight | 334.80 |