950913-56-1

950913-56-1 structure
950913-56-1 structure
  • Name: EFdA-TP
  • Chemical Name: EFdA-TP
  • CAS Number: 950913-56-1
  • Molecular Formula: C12H15FN5O12P3
  • Molecular Weight: 533.19
  • Catalog: Signaling Pathways Anti-infection HIV
  • Create Date: 2021-09-12 04:44:25
  • Modify Date: 2024-01-10 10:07:12
  • EFdA-TP is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP inhibits HIV-1 RT with multiple mechanisms[1].

Name EFdA-TP
Description EFdA-TP is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP inhibits HIV-1 RT with multiple mechanisms[1].
Related Catalog
Target

HIV-1

In Vitro EFdA-TP (0.05-10 μM; for 15 min) inhibits RT-catalyzed DNA synthesis as an ICT or DCT[1]. EFdA-TP can block RT as a translocation-defective RT inhibitor that dramatically slows DNA synthesis, acting as a de facto immediate chain terminator. EFdA-TP can function as a delayed chain terminator, allowing incorporation of an additional dNTP before blocking DNA synthesis[1].
References

[1]. Eleftherios Michailidis, et al. 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms. J Biol Chem. 2014 Aug 29;289(35):24533-48.

[2]. Martin Markowitz, et al. 4'-Ethynyl-2-fluoro-2'-deoxyadenosine, MK-8591: a novel HIV-1 reverse transcriptase translocation inhibitor. Curr Opin HIV AIDS. 2018 Jul;13(4):294-299.

Molecular Formula C12H15FN5O12P3
Molecular Weight 533.19
Hazard Codes Xi
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