DC Chemicals Limited
China
Product Name: Indirubin-3′-oxime
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

667463-82-3

667463-82-3 structure

Name: Indirubin-3′-oxime
Chemical Name: Indirubin-3′-oxime
CAS Number: 667463-82-3
Molecular Formula: C₁₆H₁₁N₃O₂
Molecular Weight: 277.28
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2021-09-05 20:31:22
Modify Date: 2024-01-14 21:25:32
Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes[1][2][3].

Name	Indirubin-3′-oxime
Synonyms	MFCD02683594

Description	Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes[1][2][3].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Research Areas >> Neurological Disease Signaling Pathways >> MAPK/ERK Pathway >> JNK Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK-3β JNK1:0.8 μM (IC50) JNK2:1.4 μM (IC50) JNK3:1 μM (IC50) CDK
In Vitro	In cerebellar granule neurons (CGNs), Indirubin-3′-oxime blocks c-Jun phosphorylation induced by potassium withdrawal and prevented CGNs from apoptosis in a dose dependent manner[1]. Indirubin-3′-oxime (IDR3O) (PC12 cells; 10 μM) significantly prevent 6OHDA-induced decrease of nuclear localized MEF2D expression[2].
In Vivo	Indirubin-3′-oxime (0.05 or 0.5 mg/kg; i.p.; daily for 2 or 10 weeks) enhances tibial longitudinal growth in mice without adverse changes in bone thickness parameters[3]. Animal Model: Three-week-old C57BL/6 mice[3] Dosage: 0.05 or 0.5 mg/kg Administration: I.p.; daily for 2 or 10 weeks Result: The tibial length of mice increased in a dose-dependent manner.
References	[1]. Xie Y, et al. Indirubin-3'-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons. Neurosci Lett. 2004;367(3):355-359. [2]. Hu S, et al. Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β. J Mol Neurosci. 2015;57(4):561-570. [3]. Choi S, et al. Indirubin-3'-oxime stimulates chondrocyte maturation and longitudinal bone growth via activation of the Wnt/β-catenin pathway. Exp Mol Med. 2019;51(9):1-10. Published 2019 Sep 12.

Molecular Formula	C₁₆H₁₁N₃O₂
Molecular Weight	277.28
Storage condition	2-8°C

Hazard Codes	Xn

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