1638611-48-9
1638611-48-9 structure
- Name: JC124
- Chemical Name: JC124
- CAS Number: 1638611-48-9
- Molecular Formula: C17H19ClN2O4S
- Molecular Weight: 382.86
- Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
- Create Date: 2021-09-05 21:14:43
- Modify Date: 2024-01-15 15:42:59
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JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects[1].
| Name | JC124 |
|---|
| Description | JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects[1]. |
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| Related Catalog | |
| In Vitro | JC124 shows selective inhibition of NLRP3 inflammasome formation and activation of caspase-1, and reduction of IL-1β both in vitro[1]. |
| In Vivo | JC124 (100 mg/kg; i.p.; 4 doses; 30 min post-injury, 6, 24, and 30 h after TBI) treatment significantly decreases the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. JC124 also significantly reduces protein expression levels of NLRP3, ASC, IL-1 beta, TNFα, iNOS, and caspase-1[1]. Animal Model: Adult male Sprague-Dawley rats (3-4-months-old) bearing traumatic brain injury (TBI)[1] Dosage: 100 mg/kg Administration: i.p.; 4 doses; 30 min post-injury, 6, 24, and 30 h after TBI Result: Significantly decreased the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. |
| References |
| Molecular Formula | C17H19ClN2O4S |
|---|---|
| Molecular Weight | 382.86 |