JC124
Modify Date: 2025-08-27 11:28:25
JC124 structure
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Common Name | JC124 | ||
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| CAS Number | 1638611-48-9 | Molecular Weight | 382.86 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H19ClN2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JC124JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects[1]. |
| Name | JC124 |
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| Description | JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects[1]. |
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| Related Catalog | |
| In Vitro | JC124 shows selective inhibition of NLRP3 inflammasome formation and activation of caspase-1, and reduction of IL-1β both in vitro[1]. |
| In Vivo | JC124 (100 mg/kg; i.p.; 4 doses; 30 min post-injury, 6, 24, and 30 h after TBI) treatment significantly decreases the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. JC124 also significantly reduces protein expression levels of NLRP3, ASC, IL-1 beta, TNFα, iNOS, and caspase-1[1]. Animal Model: Adult male Sprague-Dawley rats (3-4-months-old) bearing traumatic brain injury (TBI)[1] Dosage: 100 mg/kg Administration: i.p.; 4 doses; 30 min post-injury, 6, 24, and 30 h after TBI Result: Significantly decreased the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. |
| References |
| Molecular Formula | C17H19ClN2O4S |
|---|---|
| Molecular Weight | 382.86 |
| InChIKey | LXYPQRJNQPYTQW-UHFFFAOYSA-N |
| SMILES | CNS(=O)(=O)c1ccc(CCNC(=O)c2cc(Cl)ccc2OC)cc1 |