227010-33-5
227010-33-5 structure
- Name: LDHA-IN-3
- Chemical Name: LDHA-IN-3
- CAS Number: 227010-33-5
- Molecular Formula: C13H9F3Se
- Molecular Weight: 301.17
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Lactate Dehydrogenase
- Create Date: 2021-09-13 17:59:13
- Modify Date: 2024-01-14 19:00:02
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LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC50=145.2 nM). LDHA-IN-3 can be used for the research of cancer[1].
| Name | LDHA-IN-3 |
|---|
| Description | LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC50=145.2 nM). LDHA-IN-3 can be used for the research of cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 145.2 nM (LDHA)[1] |
| In Vitro | PSTMB (0~500 μM; 48 hours; MCF-7 cells) shows cytotoxic effect[1]. PSTMB (0.01~1 μM) shows dose-dependent inhibition of LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots. PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage[1]. PSTMB can bind to LDHA protein efficiently. PSTMB induces the intrinsic pathway-mediated apoptosis of cancer cells via production of mitochondrial ROS[1]. Cell Viability Assay[1] Cell Line: MCF-7 cells Concentration: 0~500 μM Incubation Time: 48 hours Result: Showed cytotoxic effect. |
| References |
| Molecular Formula | C13H9F3Se |
|---|---|
| Molecular Weight | 301.17 |