104264-80-4
104264-80-4 structure
- Name: Manzamine A hydrochloride
- Chemical Name: Manzamine A hydrochloride
- CAS Number: 104264-80-4
- Molecular Formula: C36H45ClN4O
- Molecular Weight: 585.22
- Catalog: Signaling Pathways Anti-infection HIV
- Create Date: 2021-09-06 00:18:33
- Modify Date: 2024-01-11 10:34:45
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Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 and 1.5μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1[1][2][3][4].
| Name | Manzamine A hydrochloride |
|---|
| Description | Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 and 1.5μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1[1][2][3][4]. |
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| Related Catalog | |
| Target |
GSK-3β:10.2 μM (IC50) CDK5:1.5 μM (IC50) HIV-1 vacuolar ATPases Malaria |
| In Vitro | Manzamine A increases acidity in pancreatic cancer cells and non-malignant Vero cells. manzamine A is a potential inhibitor of autophagy by preventing autophagosome turnover. Manzamine A (10 µM; 2 hours; AsPC-1 cells) clearly induced an accumulation of p62 confirming an inhibition of autophagosome turnover[2]. Manzamine A represents an important lead structure for the development of novel antimalarial chemotherapies[3]. |
| References |
| Molecular Formula | C36H45ClN4O |
|---|---|
| Molecular Weight | 585.22 |