2374122-43-5

2374122-43-5 structure

Name	PROTAC IRAK4 degrader-3

Description	PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> IRAK Research Areas >> Inflammation/Immunology Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IRAK4
In Vitro	PROTAC IRAK4 degrader-3 (0.01~10 μM; 2 hours; PBMCs) mediated degradation is occurring in a proteasome dependent manner[1]. PROTAC IRAK4 degrader-3 (0.01~100 μM; 18 hours; PBMCs) is capable of completely blocking IL-6 secretion[1]. Western Blot Analysis[1] Cell Line: PBMCs Concentration: 0.01~10 μM Incubation Time: 2 hours Result: IRAK4 PROTAC-mediated degradation was occurring in a proteasome dependent manner.
References	[1]. Nunes J, et al. Targeting IRAK4 for Degradation with PROTACs. ACS Med Chem Lett. 2019;10(7):1081-1085. Published 2019 Jun 14.