Shanghai Nianxing Industrial Co., Ltd
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Product Name: RMC-3943
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1801764-60-2

1801764-60-2 structure

1801764-60-2 structure

Name: RMC-3943
Chemical Name: RMC-3943
CAS Number: 1801764-60-2
Molecular Formula: C₁₈H₂₂Cl₂N₆S
Molecular Weight: 425.38
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
Create Date: 2021-09-14 23:23:04
Modify Date: 2025-08-27 12:12:21
RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM)[1].

Name	RMC-3943

Description	RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
In Vitro	RMC-3943 inhibits pERK in PC9 cells, with an IC50 of 35.5 nM[1]. RMC-3943 (0-10 μM) produces a concentration-dependent inhibition of proliferation of SK-MEL-113 cells[1]. Cell Viability Assay Cell Line: SK-MEL-113 cells[1]. Concentration: 0-10 μM. Incubation Time: 7 days. Result: Inhibited cell proliferation.
References	[1]. Efficacy of SHP2 phosphatase inhibition in cancers with nucleotide-cycling oncogenic RAS, RAS-GTP dependent oncogenic BRAF and NF1 loss. BioRxiv. 2021 Aug.

Molecular Formula	C₁₈H₂₂Cl₂N₆S
Molecular Weight	425.38

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