RMC-3943

Modify Date: 2024-01-29 18:44:47

RMC-3943 structure	Common Name	RMC-3943
	CAS Number	1801764-60-2	Molecular Weight	425.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₂Cl₂N₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RMC-3943

RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM)[1].

Name	RMC-3943

Description	RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
In Vitro	RMC-3943 inhibits pERK in PC9 cells, with an IC50 of 35.5 nM[1]. RMC-3943 (0-10 μM) produces a concentration-dependent inhibition of proliferation of SK-MEL-113 cells[1]. Cell Viability Assay Cell Line: SK-MEL-113 cells[1]. Concentration: 0-10 μM. Incubation Time: 7 days. Result: Inhibited cell proliferation.
References	[1]. Efficacy of SHP2 phosphatase inhibition in cancers with nucleotide-cycling oncogenic RAS, RAS-GTP dependent oncogenic BRAF and NF1 loss. BioRxiv. 2021 Aug.

Molecular Formula	C₁₈H₂₂Cl₂N₆S
Molecular Weight	425.38

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: RMC-3943
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Get all suppliers and price by the below link:

RMC-3943 suppliers