Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Simotinib hydrochloride
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

1538617-88-7

1538617-88-7 structure

1538617-88-7 structure

Name: Simotinib hydrochloride
Chemical Name: Simotinib hydrochloride
CAS Number: 1538617-88-7
Molecular Formula: C₂₅H₂₇Cl₂FN₄O₄
Molecular Weight: 537.41
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2021-09-05 11:01:47
Modify Date: 2024-01-03 14:14:52
Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities[1].

Name	Simotinib hydrochloride

Description	Simotinib hydrochloride is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:19.9 nM (pIC50)
In Vitro	Simotinib hydrochloride inhibits in a dose-dependent manner EGFR and the growth of human A431 tumor cells with high expression of EGFR, with no significant activity on other investigated kinases[1].
In Vivo	Simotinib hydrochloride has been shown to exert its antitumor activity by inhibiting EGFR phosphorylation in nude xenograft model[1].
References	[1]. Hu XS, et al. Safety, tolerability, and pharmacokinetics of simotinib, a novel specific EGFR tyrosine kinase inhibitor, in patients with advanced non-small cell lung cancer: results of a phase Ib trial. Cancer Manag Res. 2019;11:4449-4459. Published 2019 May 13.

Molecular Formula	C₂₅H₂₇Cl₂FN₄O₄
Molecular Weight	537.41