2154342-56-8

2154342-56-8 structure
2154342-56-8 structure
  • Name: Thalidomide-NH-PEG1-NH2 hydrochloride
  • Chemical Name: Thalidomide-NH-PEG1-NH2 hydrochloride
  • CAS Number: 2154342-56-8
  • Molecular Formula: C17H21ClN4O5
  • Molecular Weight: 396.83
  • Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
  • Create Date: 2021-09-11 12:17:20
  • Modify Date: 2024-08-08 17:54:59
  • Thalidomide-NH-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Name Thalidomide-NH-PEG1-NH2 hydrochloride
Description Thalidomide-NH-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Molecular Formula C17H21ClN4O5
Molecular Weight 396.83
Hazard Codes Xi