2266569-73-5
2266569-73-5 structure
- Name: UMB298
- Chemical Name: UMB298
- CAS Number: 2266569-73-5
- Molecular Formula: C27H31ClN4O2
- Molecular Weight: 479.01
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2021-09-18 23:52:22
- Modify Date: 2024-01-14 11:08:05
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UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1].
| Name | UMB298 |
|---|
| Description | UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1]. |
|---|---|
| Related Catalog | |
| Target |
BRD4:5193 nM (IC50) |
| In Vitro | UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth[1]. UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia[1]. UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression[1]. Cell Viability Assay[1] Cell Line: MOLM13 and MM cells Concentration: 0.01~10 μM Incubation Time: 50 days Result: Inhibited cells growth. Western Blot Analysis[1] Cell Line: MOLM13 cells Concentration: 1~10 μM Incubation Time: 2 hours Result: Reduced the H3K27ac level similar to CBP30 and caused MYC depletion as a signature of CBP inhibition in acute myeloid leukemia. RT-PCR[1] Cell Line: MOLM13 cells Concentration: 3 μM Incubation Time: 2 hours Result: Down-regulated MYC expression. |
| References |
| Molecular Formula | C27H31ClN4O2 |
|---|---|
| Molecular Weight | 479.01 |