1619923-32-8

1619923-32-8 structure
1619923-32-8 structure
  • Name: BM-1244
  • Chemical Name: BM-1244
  • CAS Number: 1619923-32-8
  • Molecular Formula: C54H59ClF4N6O8S4
  • Molecular Weight: 1159.79
  • Catalog: Signaling Pathways Apoptosis Bcl-2 Family
  • Create Date: 2021-11-08 16:33:34
  • Modify Date: 2024-01-14 18:36:30
  • BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (From patent WO2019033119A1)[1].

Name BM-1244
Description BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (From patent WO2019033119A1)[1].
Related Catalog
References

[1]. Jill Hopkins, et al. Treatment of ophthalmic conditions such as macular degeneration, glaucoma, and diabetic retinopathy using pharmaceutical agents that eliminate senescent cells. WO2019033119A1.

[2]. Kim R. Unknotting the roles of Bcl-2 and Bcl-xL in cell death. Biochem Biophys Res Commun. 2005;333(2):336-343.

Molecular Formula C54H59ClF4N6O8S4
Molecular Weight 1159.79
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