2490676-18-9

2490676-18-9 structure

Name: FTX-6058
Chemical Name: FTX-6058
CAS Number: 2490676-18-9
Molecular Formula: C₂₂H₁₈FN₅O₂
Molecular Weight: 403.41
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2021-11-01 20:11:18
Modify Date: 2024-04-11 12:28:48
FTX-6058 is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). FTX-6058 can induce HbF protein expression in cell and murine models. FTX-6058 can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia[1][2].

Name	FTX-6058

Description	FTX-6058 is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). FTX-6058 can induce HbF protein expression in cell and murine models. FTX-6058 can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Epigenetics >> Histone Methyltransferase
In Vitro	FTX-6058 inhibits PRC2 via binding to EED, which induces robust HbF protein expression in both cell and murine models[2].
References	[1]. Boerner LK. Virtual meeting delivers first time drug structures. April 12, 2021. [2]. Fulcrum Therapeutics Presents Published Structure of Investigational Small Molecule FTX-6058 at the American Chemical Society (ACS) Spring 2021 Virtual Conference.

Molecular Formula	C₂₂H₁₈FN₅O₂
Molecular Weight	403.41