FTX-6058

Modify Date: 2024-04-11 12:28:48

FTX-6058 Structure
FTX-6058 structure
Common Name FTX-6058
CAS Number 2490676-18-9 Molecular Weight 403.41
Density N/A Boiling Point N/A
Molecular Formula C22H18FN5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FTX-6058


FTX-6058 is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). FTX-6058 can induce HbF protein expression in cell and murine models. FTX-6058 can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia[1][2].

 Names

Name FTX-6058

 FTX-6058 Biological Activity

Description FTX-6058 is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). FTX-6058 can induce HbF protein expression in cell and murine models. FTX-6058 can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia[1][2].
Related Catalog
In Vitro FTX-6058 inhibits PRC2 via binding to EED, which induces robust HbF protein expression in both cell and murine models[2].
References

[1]. Boerner LK. Virtual meeting delivers first time drug structures. April 12, 2021.

[2]. Fulcrum Therapeutics Presents Published Structure of Investigational Small Molecule FTX-6058 at the American Chemical Society (ACS) Spring 2021 Virtual Conference.

 Chemical & Physical Properties

Molecular Formula C22H18FN5O2
Molecular Weight 403.41
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