GNE-502

Modify Date: 2024-01-02 19:04:07

GNE-502 structure	Common Name	GNE-502
	CAS Number	1953134-16-1	Molecular Weight	471.59
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₃₀FN₃O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GNE-502

GNE-502 is an orally active and potent degrader for estrogen receptor (ER). GNE-502 can be used for the research of breast cancer[1].

Name	GNE-502

Description	GNE-502 is an orally active and potent degrader for estrogen receptor (ER). GNE-502 can be used for the research of breast cancer[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
Target	ER[1]
In Vivo	GNE-502 (10 and 100 mg/kg; p.o.) possesses sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model[1]. ..GNE-502 shows dose dependent tumor growth inhibition at 10 mg/kg and 30 mg/kg, with tumor stasis at 100 mg/kg[1]. Animal Model: Mouse[1] Dosage: 10 and 100 mg/kg (Pharmacokinetic Analysis) Administration: P.o. Result: Possessed sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model.
References	[1]. Zbieg JR, et al. Discovery of GNE-502 as an Orally Bioavailable and Potent Degrader for Estrogen Receptor Positive Breast Cancer [published online ahead of print, 2021 Aug 20]. Bioorg Med Chem Lett. 2021;128335.

Molecular Formula	C₂₅H₃₀FN₃O₃S
Molecular Weight	471.59

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GNE-502
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: GNE-502
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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