2561529-98-2

2561529-98-2 structure

Name: MRTX849 ethoxypropanoic acid
Chemical Name: MRTX849 ethoxypropanoic acid
CAS Number: 2561529-98-2
Molecular Formula: C₃₇H₄₃ClFN₇O₅
Molecular Weight: 720.23
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2021-10-27 17:20:32
Modify Date: 2024-01-11 14:24:37
MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (DC50s between 0.25 and 0.76 μM)[1][2].

Name	MRTX849 ethoxypropanoic acid

Description	MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (DC50s between 0.25 and 0.76 μM)[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRas G12C
References	[1]. Bond MJ, et al. Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs. ACS Cent Sci. 2020;6(8):1367-1375. [2]. De Vita E, et al. The Missing Link between (Un)druggable and Degradable KRAS. ACS Cent Sci. 2020;6(8):1281-1284.

Molecular Formula	C₃₇H₄₃ClFN₇O₅
Molecular Weight	720.23

Hazard Codes	Xi