MRTX849 ethoxypropanoic acid
Modify Date: 2024-01-11 14:24:37
MRTX849 ethoxypropanoic acid structure
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Common Name | MRTX849 ethoxypropanoic acid | ||
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| CAS Number | 2561529-98-2 | Molecular Weight | 720.23 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C37H43ClFN7O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MRTX849 ethoxypropanoic acidMRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (DC50s between 0.25 and 0.76 μM)[1][2]. |
| Name | MRTX849 ethoxypropanoic acid |
|---|
| Description | MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (DC50s between 0.25 and 0.76 μM)[1][2]. |
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| Related Catalog | |
| Target |
KRas G12C |
| References |
| Molecular Formula | C37H43ClFN7O5 |
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| Molecular Weight | 720.23 |
| Hazard Codes | Xi |
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