1217623-85-2
1217623-85-2 structure
- Name: Raclopride-d5 hydrochloride
- Chemical Name: Raclopride-d5 hydrochloride
- CAS Number: 1217623-85-2
- Molecular Formula: C15H16D5Cl3N2O3
- Molecular Weight: 352.27
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2021-10-07 17:47:55
- Modify Date: 2024-01-14 10:19:08
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Raclopride-d5 (hydrochloride) is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively[1][2].
| Name | Raclopride-d5 hydrochloride |
|---|
| Description | Raclopride-d5 (hydrochloride) is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively[1][2]. |
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| Related Catalog | |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References |
[2]. Seeman P, et al. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15(7):264-70. |
| Molecular Formula | C15H16D5Cl3N2O3 |
|---|---|
| Molecular Weight | 352.27 |