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1070881-42-3

1070881-42-3 structure
1070881-42-3 structure
  • Name: Terevalefim
  • Chemical Name: 3-[(E)-2-(2-Thienyl)vinyl]pyrazolidine
  • CAS Number: 1070881-42-3
  • Molecular Formula: C9H8N2S
  • Molecular Weight: 176.24
  • Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Met/HGFR
  • Create Date: 2022-03-04 11:12:11
  • Modify Date: 2024-01-14 08:29:04
  • Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor[1][2].

Name 3-[(E)-2-(2-Thienyl)vinyl]pyrazolidine
Synonyms Pyrazolidine, 3-[(E)-2-(2-thienyl)ethenyl]-
3-[(E)-2-(2-Thienyl)vinyl]pyrazolidine
Description Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor[1][2].
Related Catalog
In Vitro Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cells proliferation in HUVECs[2]. Cell Viability Assay[2] Cell Line: Human Umbilical Vein Epithelial Cells (HUVECs). Concentration: 0.44, 1.78, and 7.1 μM. Incubation Time: 24 to 48 hours. Result: Dose-dependently inhibited cell proliferation.
In Vivo Terevalefim (ANG-3777) decreases apoptosis, increases proliferation, and promotes organ repair and function in animal models[1]. Terevalefim (ANG-3777, 40 mg/kg, IP) phosphorylates the c-Met receptor in rats[2]. Animal Model: SD rats[2]. Dosage: 40 mg/kg. Administration: IP injection, once. Result: Selectively phosphorylated the c-Met receptor and not other growth factor receptors.
References

[1]. Jonathan S Bromberg, et al. Renal Function Improvement Following ANG-3777 Treatment in Patients at High Risk for Delayed Graft Function After Kidney Transplantation. Transplantation. 2021 Feb 1;105(2):443-450.

[2]. Latha Paka, et al. The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor, c-MET Signaling. American Transplant Society.

Density 1.2±0.1 g/cm3
Boiling Point 288.0±29.0 °C at 760 mmHg
Molecular Formula C9H8N2S
Molecular Weight 176.24
Flash Point 128.0±24.3 °C
Exact Mass 180.072113
LogP 1.31
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.681