1496997-41-1

1496997-41-1 structure

Name: Thalidomide-5,6-F
Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione
CAS Number: 1496997-41-1
Molecular Formula: C₁₃H₈F₂N₂O₄
Molecular Weight: 294.21
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2021-12-23 18:06:05
Modify Date: 2025-08-25 13:16:15
Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs[1].

Name	2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione
Synonyms	MFCD32853274 2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5,6-difluoro-

Description	Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Liu K, et al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013;11(29):4757-4763.

Hazard Codes	Xi