Thalidomide-5,6-F
Modify Date: 2024-01-09 17:45:00
Thalidomide-5,6-F structure
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Common Name | Thalidomide-5,6-F | ||
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| CAS Number | 1496997-41-1 | Molecular Weight | 294.21 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 534.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C13H8F2N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 277.1±30.1 °C | |
Use of Thalidomide-5,6-FThalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs[1]. |
| Name | 2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione |
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| Synonym | More Synonyms |
| Description | Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs[1]. |
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| Related Catalog | |
| Target |
Cereblon |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 534.6±50.0 °C at 760 mmHg |
| Molecular Formula | C13H8F2N2O4 |
| Molecular Weight | 294.21 |
| Flash Point | 277.1±30.1 °C |
| Exact Mass | 294.045227 |
| LogP | 0.55 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.609 |
| Hazard Codes | Xi |
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| MFCD32853274 |
| 2-(2,6-Dioxo-3-piperidinyl)-5,6-difluoro-1H-isoindole-1,3(2H)-dione |
| 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5,6-difluoro- |