1628870-27-8

1628870-27-8 structure

Name: Itacnosertib
Chemical Name: (6E)-6-(2,2'-Bipyridin-3-ylimino)-N-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-1,6-dihydro-2-pyrimidinamine
CAS Number: 1628870-27-8
Molecular Formula: C₂₆H₂₈N₈O
Molecular Weight: 468.55
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2022-01-14 10:23:04
Modify Date: 2025-08-26 14:36:05
Itacnosertib (TP-0184) is both inhibitor to JAK2, ACVR1 (ALK2) and ALK5 as described in WO2014151871[1].

Name	(6E)-6-(2,2'-Bipyridin-3-ylimino)-N-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-1,6-dihydro-2-pyrimidinamine
Synonyms	(6E)-6-(2,2'-Bipyridin-3-ylimino)-N-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-1,6-dihydro-2-pyrimidinamine 2-Pyrimidinamine, 6-([2,2'-bipyridin]-3-ylimino)-1,6-dihydro-N-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-, (6E)-

Description	Itacnosertib (TP-0184) is both inhibitor to JAK2, ACVR1 (ALK2) and ALK5 as described in WO2014151871[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
References	[1]. Mollard, Alexis; Warner, Steven L.; Flynn, Gary A.; Vankayalapati, Hariprasad; Bearss, David J. Preparation of [(piperazinylphenyl)amino]pyrimidine derivatives as JAK2 and ALK2 inhibitors. WO2014151871 A2