192384-87-5
192384-87-5 structure
- Name: BP 897
- Chemical Name: BP-897
- CAS Number: 192384-87-5
- Molecular Formula: C26H31N3O2
- Molecular Weight: 417.54
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2022-01-28 10:42:51
- Modify Date: 2024-02-04 17:48:33
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BP 897 is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM). BP 897 exhibits selective inhibition of cocaine-seeking behavior[1].
| Name | BP-897 |
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| Synonyms |
N-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-2-naphthamide
MFCD04039996 N-{4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl}-2-naphthamide BP-897 DO-687 N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}naphthalene-2-carboxamide N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide 2FVL90IM8I 2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- BP897 |
| Description | BP 897 is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM). BP 897 exhibits selective inhibition of cocaine-seeking behavior[1]. |
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| Related Catalog | |
| In Vitro | BP 897 also displays low affinities at D1 and D4 receptors (Ki=3 and 0.3 μM, respectively), as well as at α1 and α2 adrenergic receptors (Ki=60 and 83 nM, respectively), 5HT1A and 5HT7 receptors (Ki=84 and 345 nM, respectively), and negligible affinities (Ki>1 μM) atmuscarinic, histamine and opiate receptors[1]. In NG 108-15 cells expressing the human D3 receptor, BP 897 inhibits forskolin-induced cyclic AMP accumulation with an EC50 of 1 nM. BP 897 activates mitogenesis and this response is antagonized by the preferential D3 receptor antagonist Nafadotride (1 μM). BP 897 also partially antagonized the response induced by quinpirole (10 nM)[1]. |
| In Vivo | BP 897 (0.05, 0.5, 1 mg/kg; i.p.; 30 min before the session) reduces cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression[1]. Animal Model: Male Listar hooded rats[1] Dosage: 0.05, 0.5, 1 mg/kg Administration: i.p.; 30 min before the session Result: Reduced cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 654.5±55.0 °C at 760 mmHg |
| Molecular Formula | C26H31N3O2 |
| Molecular Weight | 417.54 |
| Flash Point | 349.6±31.5 °C |
| Exact Mass | 417.241638 |
| LogP | 4.52 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.606 |