753015-44-0

753015-44-0 structure

Name: Simpinicline
Chemical Name: 5-[(E)-2-(3-Pyrrolidinyl)vinyl]pyrimidine
CAS Number: 753015-44-0
Molecular Formula: C₁₀H₁₃N₃
Molecular Weight: 175.23
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2021-12-19 08:31:31
Modify Date: 2025-08-29 18:18:16
Simpinicline (OC-02), a highly selective nicotinic acetylcholine receptor (nAChR) agonist, shows potent antiviral activity against the SARS-CoV-2 variants in cell culture with an IC50 of 0.04 µM[1].

Name	5-[(E)-2-(3-Pyrrolidinyl)vinyl]pyrimidine
Synonyms	Pyrimidine, 5-[(E)-2-(3-pyrrolidinyl)ethenyl]- 5-[(E)-2-(3-Pyrrolidinyl)vinyl]pyrimidine

Description	Simpinicline (OC-02), a highly selective nicotinic acetylcholine receptor (nAChR) agonist, shows potent antiviral activity against the SARS-CoV-2 variants in cell culture with an IC50 of 0.04 µM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR
References	[1]. Quik M, et al. α4β2 Nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats. Neuropharmacology. 2013 Aug;71:191-203.

Molecular Formula	C₁₀H₁₃N₃
Molecular Weight	175.23