Simpinicline

Modify Date: 2025-08-29 18:18:16

Simpinicline Structure
Simpinicline structure
Common Name Simpinicline
CAS Number 753015-44-0 Molecular Weight 175.23
Density N/A Boiling Point N/A
Molecular Formula C10H13N3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Simpinicline


Simpinicline (OC-02), a highly selective nicotinic acetylcholine receptor (nAChR) agonist, shows potent antiviral activity against the SARS-CoV-2 variants in cell culture with an IC50 of 0.04 µM[1].

 Names

Name 5-[(E)-2-(3-Pyrrolidinyl)vinyl]pyrimidine
Synonym More Synonyms

 Simpinicline Biological Activity

Description Simpinicline (OC-02), a highly selective nicotinic acetylcholine receptor (nAChR) agonist, shows potent antiviral activity against the SARS-CoV-2 variants in cell culture with an IC50 of 0.04 µM[1].
Related Catalog
References

[1]. Quik M, et al. α4β2 Nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats. Neuropharmacology. 2013 Aug;71:191-203.

 Chemical & Physical Properties

Molecular Formula C10H13N3
Molecular Weight 175.23

 Synonyms

Pyrimidine, 5-[(E)-2-(3-pyrrolidinyl)ethenyl]-
5-[(E)-2-(3-Pyrrolidinyl)vinyl]pyrimidine
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