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104112-82-5

104112-82-5 structure
104112-82-5 structure
  • Name: Phellodendrine chloride
  • Chemical Name: Phellodendrine chloride
  • CAS Number: 104112-82-5
  • Molecular Formula: C20H24ClNO4
  • Molecular Weight: 377.862
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-05-25 08:00:00
  • Modify Date: 2024-01-02 21:30:51
  • Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1].
Name Phellodendrine chloride
Synonyms 6H-Dibenzo[a,g]quinolizinium, 5,8,13,13a-tetrahydro-2,11-dihydroxy-3,10-dimethoxy-7-methyl-, chloride, (13aS)- (1:1)
(13aS)-2,11-Dihydroxy-3,10-dimethoxy-7-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolinium chloride
Description Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1].
Related Catalog
References

[1]. Thu PM, et al. Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis. Eur J Pharmacol. 2019 May 5;850:23-34.
Melting Point 249-251℃ (methanol )
Molecular Formula C20H24ClNO4
Molecular Weight 377.862
Exact Mass 377.139374
PSA 58.92000
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DR9848050
CHEMICAL NAME :
13a-alpha-Berbinium, 2,11-dihydroxy-3,10-dimethoxy-7-methyl-, chloride
CAS REGISTRY NUMBER :
104112-82-5
LAST UPDATED :
198909
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H24-N-O4.Cl
MOLECULAR WEIGHT :
377.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
69500 ug/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 58,138,1962
Safety Phrases 24/25

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title: CAS No. 104112-82-5 | Chemsrc address: https://m.chemsrc.com/en/baike/168717.html

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