Phellodendrine chloride

Modify Date: 2024-01-02 21:30:51

Phellodendrine chloride structure	Common Name	Phellodendrine chloride
	CAS Number	104112-82-5	Molecular Weight	377.862
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₄ClNO₄	Melting Point	249-251℃ (methanol )
	MSDS	N/A	Flash Point	N/A

Use of Phellodendrine chloride

Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1].

Name	Phellodendrine chloride
Synonym	More Synonyms

Description	Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Thu PM, et al. Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis. Eur J Pharmacol. 2019 May 5;850:23-34.

Melting Point	249-251℃ (methanol )
Molecular Formula	C₂₀H₂₄ClNO₄
Molecular Weight	377.862
Exact Mass	377.139374
PSA	58.92000
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9848050

CHEMICAL NAME :: 13a-alpha-Berbinium, 2,11-dihydroxy-3,10-dimethoxy-7-methyl-, chloride

CAS REGISTRY NUMBER :: 104112-82-5

LAST UPDATED :: 198909

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H24-N-O4.Cl

MOLECULAR WEIGHT :: 377.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 69500 ug/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 58,138,1962