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1404019-95-9

1404019-95-9 structure
1404019-95-9 structure
  • Name: Lademirsen
  • Chemical Name: Lademirsen
  • CAS Number: 1404019-95-9
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Signaling Pathways Epigenetics MicroRNA
  • Create Date: 2021-12-27 17:11:44
  • Modify Date: 2024-01-11 07:02:45
  • Lademirsen (SAR339375; RG-012) is a highly specific antisense oligonucleotide (ASO) targeting miR-21. Lademirsen has the potential for Alport nephropathy research[1][2].

Name Lademirsen
Description Lademirsen (SAR339375; RG-012) is a highly specific antisense oligonucleotide (ASO) targeting miR-21. Lademirsen has the potential for Alport nephropathy research[1][2].
Related Catalog
In Vivo Administration of Lademirsen (SAR339375; RG-012) to inhibit miR-21 leads to a slowed progression of renal fibrosis and an increased lifespan in Alport syndrome mouse models[1].
References

[1]. Ivan G Gomez, et al. Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways. J Clin Invest. 2015 Jan;125(1):141-56.

[2]. Chiranjib Chakraborty, et al. Therapeutic advances of miRNAs: A preclinical and clinical update. J Adv Res. 2020 Aug 29;28:127-138.

No Any Chemical & Physical Properties
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