2407457-55-8

2407457-55-8 structure

Name: OICR-9429-N-C2-NH2
Chemical Name: OICR-9429-N-C2-NH2
CAS Number: 2407457-55-8
Molecular Formula: C₃₁H₃₈F₃N₇O₂
Molecular Weight: 597.67
Catalog: Research Areas Cancer
Create Date: 2022-01-06 18:51:59
Modify Date: 2024-01-20 15:58:25
OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs[1].

Name	OICR-9429-N-C2-NH2

Description	OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer
Target	Ligand for Target Protein for PROTAC[1]
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation / disruption compounds and methods of use. WO2019246570A1. [2]. Chung CW, et, al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323.