2245697-87-2

2245697-87-2 structure

Name: Thalidomide-NH-PEG2-C2-NH2 hydrochloride
Chemical Name: Thalidomide-NH-PEG2-C2-NH2 hydrochloride
CAS Number: 2245697-87-2
Molecular Formula: C₁₉H₂₅ClN₄O₆
Molecular Weight: 440.88
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-06-01 16:07:29
Modify Date: 2024-01-06 12:08:02
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

Name	Thalidomide-NH-PEG2-C2-NH2 hydrochloride

Description	Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

Molecular Formula	C₁₉H₂₅ClN₄O₆
Molecular Weight	440.88

Hazard Codes	Xi