79125-22-7
79125-22-7 structure
- Name: Bopindolol fumarate
- Chemical Name: Bopindolol fumarate
- CAS Number: 79125-22-7
- Molecular Formula: C27H32N2O7
- Molecular Weight: 496.55
- Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
- Create Date: 2022-03-04 09:31:18
- Modify Date: 2024-01-03 13:50:22
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Bopindolol ((±)-Bopindolol) fumarate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol fumarate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol fumarate is a prodrug of pindolol and can be used for essential and renovascular hypertension research[1][2].
| Name | Bopindolol fumarate |
|---|
| Description | Bopindolol ((±)-Bopindolol) fumarate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol fumarate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol fumarate is a prodrug of pindolol and can be used for essential and renovascular hypertension research[1][2]. |
|---|---|
| Related Catalog | |
| Target |
β1 adrenoceptor β2 adrenoceptor β3 adrenoceptor |
| In Vivo | Bopindolol (intravenous injection; l8, 16 and 32 μg/kg) fumarate causes a dose-dependent inhibition of isoprenaline-induced tachycardia, and this agent is 4 times more potent than propranolol in anaesthetised dogs[1]. Bopindolol (intraperitoneal injection; 3.0 mg/kg) fumarate reduces the diastolic blood pressure (DBP) in pithed rats. And pindolol (1.0 mg/kg) produces similar decreases in DBP of about 8 mmHg. it also produces a dose-dependent decrease in heart rate[2]. |
| References |
| Molecular Formula | C27H32N2O7 |
|---|---|
| Molecular Weight | 496.55 |