2421141-40-2

2421141-40-2 structure

Name: GLUT inhibitor-1
Chemical Name: GLUT inhibitor-1
CAS Number: 2421141-40-2
Molecular Formula: C₃₂H₃₅N₇O₂
Molecular Weight: 549.67
Catalog: Research Areas Cancer
Create Date: 2022-03-07 12:43:10
Modify Date: 2024-01-02 20:18:43
GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases[1].

Name	GLUT inhibitor-1

Description	GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology
Target	GLUT1:242 nM (IC50) GLUT3:179 nM (IC50)
In Vivo	Summary of the pharmacokinetic parameters of GLUT inhibitor-1 (compound 15b; 30 mg/kg) in mouse and rat[1]. Parameter Mouse Rat oral Cmax (ng/mL) 2525 1675 oral AUC (ng/mL) 5890 6813 CL (mL/min/kg) 40 37 Vdss (L/Kg) 1.70 4.51 t1/2 (h) 0.785 2.59 F (%) 45.4 49.4 B/Pb 0.05 b: Solubility is determined in PBS buffer solutions.
References	[1]. Liu KG, et al. Discovery and Optimization of Glucose Uptake Inhibitors. J Med Chem. 2020;63(10):5201-5211.

Molecular Formula	C₃₂H₃₅N₇O₂
Molecular Weight	549.67