863193-70-8

863193-70-8 structure

Name: Fenlean
Chemical Name: Fenlean
CAS Number: 863193-70-8
Molecular Formula: C₂₆H₂₇NO₆
Molecular Weight: 449.50
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Src
Create Date: 2022-03-26 11:19:21
Modify Date: 2026-07-02 02:29:10
Fenlean, a natural squamosamide derivative, is a Src tyrosine kinase inhibitor. Fenlean can inhibit over-activated microglia and protect dopaminergic neurons. Fenlean can attenuate neuroinflammation in Parkinson's disease models[1][2][3].

Name	Fenlean
Synonyms	Benzeneacetamide, α-[(4-hydroxy-3-methoxyphenyl)methylene]-N-[2-(4-hydroxyphenyl)ethyl]-2,5-dimethoxy

Description	Fenlean, a natural squamosamide derivative, is a Src tyrosine kinase inhibitor. Fenlean can inhibit over-activated microglia and protect dopaminergic neurons. Fenlean can attenuate neuroinflammation in Parkinson's disease models[1][2][3].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	Src tyrosine kinase[1]
References	[1]. Tai W, et, al. Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models. Neuropharmacology. 2013 Dec;75:201-12. [2]. Cheng LB, et, al. Squamosamide derivative FLZ protects retinal pigment epithelium cells from oxidative stress through activation of epidermal growth factor receptor (EGFR)-AKT signaling. Int J Mol Sci. 2014 Oct 17;15(10):18762-75. [3]. Ye X, et, al. FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells. Naunyn Schmiedebergs Arch Pharmacol. 2014 Jan;387(1):75-85.

Molecular Formula	C₂₆H₂₇NO₆
Molecular Weight	449.50