Fenlean

Modify Date: 2025-08-24 20:55:03

Fenlean structure	Common Name	Fenlean
	CAS Number	863193-70-8	Molecular Weight	449.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₇NO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Fenlean

Fenlean, a natural squamosamide derivative, is a Src tyrosine kinase inhibitor. Fenlean can inhibit over-activated microglia and protect dopaminergic neurons. Fenlean can attenuate neuroinflammation in Parkinson's disease models[1][2][3].

Name	Fenlean

Description	Fenlean, a natural squamosamide derivative, is a Src tyrosine kinase inhibitor. Fenlean can inhibit over-activated microglia and protect dopaminergic neurons. Fenlean can attenuate neuroinflammation in Parkinson's disease models[1][2][3].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	Src tyrosine kinase[1]
References	[1]. Tai W, et, al. Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models. Neuropharmacology. 2013 Dec;75:201-12. [2]. Cheng LB, et, al. Squamosamide derivative FLZ protects retinal pigment epithelium cells from oxidative stress through activation of epidermal growth factor receptor (EGFR)-AKT signaling. Int J Mol Sci. 2014 Oct 17;15(10):18762-75. [3]. Ye X, et, al. FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells. Naunyn Schmiedebergs Arch Pharmacol. 2014 Jan;387(1):75-85.

Molecular Formula	C₂₆H₂₇NO₆
Molecular Weight	449.50
InChIKey	ZZTHOXZXWINLQI-HYARGMPZSA-N
SMILES	COc1ccc(OC)c(C(=Cc2ccc(O)c(OC)c2)C(=O)NCCc2ccc(O)cc2)c1

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Fenlean

Use of Fenlean

Names

Fenlean Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.