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1883300-48-8

1883300-48-8 structure

1883300-48-8 structure

Name: JAK1/TYK2-IN-1
Chemical Name: JAK1/TYK2-IN-1
CAS Number: 1883300-48-8
Molecular Formula: C₁₈H₂₀F₃N₇O
Molecular Weight: 407.39
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2022-03-23 16:57:27
Modify Date: 2026-07-28 20:57:02
JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 (IC50 = 29 and 41 nM respectively).

Name	JAK1/TYK2-IN-1
Synonyms	Cyclopropanecboxamide, 2,2-difluoro-N-[(1S,5R,6R)-3-[5-fluoro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-6-methyl-3-azabicyclo[3.1.0]hex-1-yl]-, (1S)

Description	JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 (IC50 = 29 and 41 nM respectively).
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK
References	[1]. Fensome A, et al. Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Bioorg Med Chem. 2020 May 15;28(10):115481.

Molecular Formula	C₁₈H₂₀F₃N₇O
Molecular Weight	407.39

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