2647464-92-2

2647464-92-2 structure

Name: CXCR2 antagonist 3
Chemical Name: CXCR2 antagonist 3
CAS Number: 2647464-92-2
Molecular Formula: C₁₇H₁₅FN₂O₄S
Molecular Weight: 362.38
Catalog: Signaling Pathways GPCR/G Protein CXCR
Create Date: 2022-04-28 19:31:11
Modify Date: 2024-01-13 18:31:52
CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues[1].

Name	CXCR2 antagonist 3

Description	CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> CXCR Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> CXCR
References	[1]. Dong Y, et al. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. J Med Chem. 2021;64(22):16626-16640.

Molecular Formula	C₁₇H₁₅FN₂O₄S
Molecular Weight	362.38