CXCR2 antagonist 3

Modify Date: 2025-08-21 22:45:46

CXCR2 antagonist 3 Structure
CXCR2 antagonist 3 structure
Common Name CXCR2 antagonist 3
CAS Number 2647464-92-2 Molecular Weight 362.38
Density N/A Boiling Point N/A
Molecular Formula C17H15FN2O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CXCR2 antagonist 3


CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues[1].

 Names

Name CXCR2 antagonist 3

 CXCR2 antagonist 3 Biological Activity

Description CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues[1].
Related Catalog
References

[1]. Dong Y, et al. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. J Med Chem. 2021;64(22):16626-16640.

 Chemical & Physical Properties

Molecular Formula C17H15FN2O4S
Molecular Weight 362.38
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