2420562-65-6

2420562-65-6 structure

Name: IHCH-3064
Chemical Name: IHCH-3064
CAS Number: 2420562-65-6
Molecular Formula: C₂₅H₂₁N₉O₂
Molecular Weight: 479.49
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-04-18 21:56:57
Modify Date: 2024-01-08 21:47:15
IHCH-3064 is a dual-acting compounds targeting Adenosine A2A Receptor and HDAC. IHCH-3064 exhibits potent binding to A2AR (Ki=2.2 nM) and selective inhibition of HDAC1 (IC50=80.2 nM), with good antiproliferative activity against tumor cell lines in vitro. IHCH-3064 is a tumor immunotherapeutic agent[1].

Name	IHCH-3064

Description	IHCH-3064 is a dual-acting compounds targeting Adenosine A2A Receptor and HDAC. IHCH-3064 exhibits potent binding to A2AR (Ki=2.2 nM) and selective inhibition of HDAC1 (IC50=80.2 nM), with good antiproliferative activity against tumor cell lines in vitro. IHCH-3064 is a tumor immunotherapeutic agent[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Signaling Pathways >> Epigenetics >> HDAC
References	[1]. Wenzhong Yan, et al. Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A 2A Receptor and Histone Deacetylase as Novel Tumor Immunotherapeutic Agents. J Med Chem. 2021 Nov 25;64(22):16573-16597.

Molecular Formula	C₂₅H₂₁N₉O₂
Molecular Weight	479.49